Pharmaceuticals2024

GMP-Compliant Tablet Line Automation

Full batch automation and machine vision quality system for a pharmaceutical manufacturer

Client
Meridian Pharma Industries
Duration
6 months
Year
2024
Technologies
Allen-Bradley ControlLogix PLCCognex Vision SystemIgnition SCADA21 CFR Part 11 eBMRERPNext Integration
+19%
OEE
-65%
Batch Record Time
99.7%
Defect Detection
100%
Compliance Status
The Challenge

A pharmaceutical tablet manufacturer was running coating and packaging lines with minimal automation. Batch records were paper-based, quality inspection was 100% manual, and regulatory submissions were consuming significant quality team time. OEE was at 61% against a target of 80%.

The Solution

Peunier designed and deployed a fully automated tablet coating and packaging line with 21 CFR Part 11 compliant electronic batch records, inline machine vision inspection, and SCADA integration with the client's existing ERP system.

Our Approach
01

GMP Compliance Assessment

Mapped existing documentation practices against 21 CFR Part 11 and EU GMP Annex 11 requirements. Identified 23 compliance gaps to be addressed.

02

Automation System Design

Designed Allen-Bradley PLC-based control architecture for coating, blister packaging, and cartoning lines with full interlock and safety logic.

03

Machine Vision Integration

Deployed 4 camera inspection stations for tablet appearance, blister fill verification, and print check with <50ms cycle time.

04

eBMR System Development

Built custom electronic batch manufacturing record system with audit trail, electronic signatures, and SCADA data auto-population.

05

Validation & Commissioning

Full IQ/OQ/PQ validation protocol execution with documentation package for regulatory submission.

Measurable Results
+19%
OEE
From 61% to 80% in 6 months
-65%
Batch Record Time
Reduction in batch record completion time
99.7%
Defect Detection
Vision system accuracy vs 94% manual inspection
100%
Compliance Status
All 23 identified compliance gaps resolved
"

The validation package Peunier delivered was comprehensive enough to sail through our regulatory inspection without a single observation. The quality of their documentation matched our internal standards.

PS
Dr. Priya Sharma
Head of Quality Assurance, Meridian Pharma Industries